Table 3.
Baseline | Dose 1 | Dose 2 | Dose 3 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FBF | MAP | HR | FBF | MAP | HR | FBF | MAP | HR | FBF | MAP | HR | ||
ADO | Young | 1.7 ± 0.3 | 91 ± 3 | 60 ± 5 | 4.5 ± 0.9 | 94 ± 4 | 58 ± 4 | 6.2 ± 0.9 | 95 ± 4 | 59 ± 4 | 7.0 ± 0.8 | 95 ± 5 | 58 ± 5 |
Young + APH | 2.0 ± 0.5 | 93 ± 4 | 57 ± 5 | 4.1 ± 0.9 | 98 ± 5 | 58 ± 4 | 4.8 ± 1.0 | 97 ± 5 | 57 ± 4 | 5.6 ± 1.2 | 98 ± 6 | 58 ± 4 | |
Older | 1.2 ± 0.2 | 98 ± 5 | 57 ± 2 | 3.6 ± 0.8 | 99 ± 5 | 58 ± 2 | 4.8 ± 0.9 | 99 ± 5 | 57 ± 2 | 5.6 ± 1.1 | 100 ± 4 | 58 ± 2 | |
Older + APH | 1.2 ± 0.3 | 102 ± 6 | 56 ± 2 | 2.9 ± 1.1 | 102 ± 6 | 56 ± 2 | 3.5 ± 1.4† | 101 ± 6 | 56 ± 2 | 3.9 ± 1.5 | 102 ± 7 | 58 ± 2 | |
ATP | Young | 1.8 ± 0.3 | 92 ± 5 | 59 ± 5 | 5.8 ± 1.2 | 93 ± 4 | 59 ± 5 | 7.5 ± 1.5 | 93 ± 5 | 58 ± 5 | 9.1 ± 1.7 | 93 ± 5 | 59 ± 5 |
Young + APH | 2.0 ± 0.3 | 92 ± 5 | 58 ± 5 | 6.2 ± 1.0 | 98 ± 5 | 57 ± 4 | 7.3 ± 1.1 | 96 ± 5 | 59 ± 4 | 8.6 ± 1.2 | 97 ± 5 | 58 ± 4 | |
Older | 1.3 ± 0.2 | 98 ± 3 | 58 ± 2 | 4.7 ± 0.9 | 98 ± 4 | 58 ± 1 | 5.8 ± 1.4 | 102 ± 5 | 57 ± 2 | 7.4 ± 1.1 | 99 ± 4 | 57 ± 2 | |
Older + APH | 1.3 ± 0.2 | 98 ± 5 | 56 ± 1 | 4.6 ± 1.0 | 102 ± 5 | 56 ± 2 | 5.4 ± 1.1 | 102 ± 5 | 56 ± 2 | 6.5 ± 1.0 | 101 ± 6 | 57 ± 2 |
APH, aminophylline; ADO, adenosine; FBF, forearm blood flow (ml (100 ml)−1 min−1); MAP, mean arterial pressure (mmHg); HR, heart rate (beats min−1).