Table 2.
GH-, IGF-, Wnt-, and BMP-associated genes acutely regulated by GH in bone (P ≤ 0.05)
| Common Name | 6 h | 24 h | Description | GenBank |
|---|---|---|---|---|
| GH-IGF axis | ||||
| Igf1 | 2.60 | 2.29 | Insulin-like growth factor I (Igf1), mRNA | AK038119 |
| Igf2 | 2.01 | Insulin-like growth factor II (Igf2), mRNA | NM_010514 | |
| Igfbp2 | 0.75 | Insulin-like growth factor-binding protein 2 (Igfbp2), mRNA | AK011784 | |
| Igfbp3 | 1.37 | 1.54 | Insulin-like growth factor-binding protein 3 (Igfbp3), mRNA | AK077477 |
| Igf2bp1 (IMP1) | 2.11 | 2.55 | Insulin-like growth factor II-binding protein 1 (Igf2bp1), mRNA | AK013940 |
| Igf2bp3 (IMP3) | 0.87 | Insulin-like growth factor II-binding protein 3 (Igf2bp3), mRNA | AK011689 | |
| Ghitm | 0.72 | Growth hormone-inducible transmembrane protein (Ghitm), mRNA | AK005636 | |
| Stat1 | 0.44 | Signal transducer and activator of transcription 1 (Stat1), mRNA | AK018544 | |
| Stat4 | 0.40 | Signal transducer and activator of transcription 4 (Stat4), mRNA | AK037598 | |
| Stat5a | 0.60 | Signal transducer and activator of transcription 5A (Stat5a), mRNA | AK090254 | |
| Stat6 | 1.42 | Signal transducer and activator of transcription 6 (Stat6), mRNA | NM_009284 | |
| Wnt signaling | ||||
| Wnt5a | 1.87 | 2.03 | Wingless-related MMTV integration site 5A | AK031512 |
| Dvl2 | 0.83 | 0.81 | Dishevelled 2, dsh homolog (Drosophila) (Dvl2), mRNA | NM_007888 |
| Axin | 0.94 | Axin 1 (axis inhibition protein 1) (fused protein) (fragment). | XM_128515 | |
| Wif1 | 1.33 | Wnt inhibitory factor 1 (Wif1), mRNA | AK077698 | |
| Fbxw4 | 1.43 | F-box and WD-40 domain protein 4 (Fbxw4), mRNA | AK004414 | |
| Csnk2a2 | 0.53 | Casein kinase II, alpha 2, polypeptide (Csnk2a2), mRNA | AK002927 | |
| Frzb | 0.55 | Frizzled-related protein (Frzb), mRNA | AK019093 | |
| Tle2 | 0.69 | Transducin-like enhancer of split 2, homolog (Drosophila) E(spl) (Tle2), mRNA | NM_019725 | |
| Apc | 1.05 | Adenomatosis polyposis coli (Apc), mRNA | AK042021 | |
| Csnk1a1 | 2.31 | Casein kinase 1, alpha 1 (Csnk1a1), mRNA | AK012299 | |
| BMP-associated genes | ||||
| Bmp2 | 0.74 | 0.78 | Bone morphogenetic protein 2 (Bmp2), mRNA | NM_007553 |
| Bmp4 | 0.86 | Bone morphogenetic protein 4 (Bmp4), mRNA | NM_007554 | |
| Bmp7 | 0.51 | Bone morphogenetic protein 7 (Bmp7), mRNA | AK020411 | |
| Madh5 | 2.77 | MAD homolog 5 (Drosophila) (Madh5), mRNA | AK018077 | |