Table III.
Association between sports/recreational physical activity and hormones/peptides: Means ± SE among a sample of 710 women with breast cancer
| Tertile 1 (< 2.6 METhr/wk) | Tertile 2 (2.6 – 13.2 METhr/wk) | Tertile 3 (≥ 13.3 METhr/wk) | P for trend | |
|---|---|---|---|---|
| Mean ± SE (n = 236) | Mean ± SE (n = 238) | Mean ± SE (n = 236) | ||
| C-Peptide (ng/mL) | ||||
| Unadjusted | 2.49 ± 0.07 | 2.34 ± 0.07 | 2.04 ± 0.07b,c | .001 |
| Adjusted1 | 2.48 ± 0.07 | 2.35 ± 0.07 | 2.04 ± 0.07b,c | .001 |
| Adjusted2 | 2.33 ± 0.06 | 2.35 ± 0.06 | 2.19 ± 0.06 | .13 |
| Leptin (ng/mL) | ||||
| Unadjusted | 30.5 ± 1.1 | 24.5 ± 1.1a | 18.9 ± 1.1b,c | .001 |
| Adjusted1 | 30.0 ± 1.1 | 24.5 ± 1.1a | 19.4 ± 1.1b,c | .001 |
| Adjusted2 | 26.1 ± 0.8 | 24.3 ± 0.8 | 23.4 ± 0.8b | .020 |
| IGF-I (ng/mL) | ||||
| Unadjusted | 119.7 ± 3.7 | 136.1 ± 3.7a | 144.7 ±3.7b | .0001 |
| Adjusted1 | 125.8 ± 3.4 | 134.9 ± 3.3a | 140.0 ±3.4b | .0037 |
| Adjusted2 | 129.5 ± 3.4 | 135.0 ± 3.3 | 136.2 ±3.4b | .018 |
| IGFBP-3 (ug/mL) | ||||
| Unadjusted | 3.96 ± 0.06 | 4.09 ± 0.06 | 4.18 ± 0.06b | .011 |
| Adjusted1 | 3.99 ± 0.06 | 4.08 ± 0.06 | 4.16 ± 0.06b | .055 |
| Adjusted2 | 4.02 ± 0.06 | 4.08 ± 0.06 | 4.14 ± 0.06 | .17 |
| IGF-I: IGFBP-3 (ng/mL) | ||||
| Unadjusted | 30.2 ± 0.8 | 33.5 ± 0.8a | 34.5 ± 0.8b | .0001 |
| Adjusted1 | 31.3 ± 0.7 | 33.3 ± 0.7a | 33.6 ± 0.7b | .024 |
| Adjusted2 | 32.1 ± 0.4 | 33.3 ± 0.7 | 32.8 ± 0.7 | .47 |
1
Adjusted for study site, age, ethnicity, education, menopausal status, disease stage, adjuvant treatment, tamoxifen use, type 2 diabetes, and smoking status.
2
Adjusted for all the above covariates including body mass index.
a
Tertile 2 significantly different from Tertile 1, p < .05.
b
Tertile 3 significantly different from Tertile 1, p < .05.
c
Tertile 3 significantly different from Tertile 2, p < .05.