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. 2011 Jan 1;14(1):25–35. doi: 10.1089/ars.2010.3095

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Copyright 2011, Mary Ann Liebert, Inc.

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FIG. 2. — Upregulation of I_to density by JNK and p38 inhibitors. (A) Superimposed current traces are shown for myocytes from post-MI hearts untreated or treated with the JNK inhibitor SP600125 (10 (μM) for 4–5 h. (B) Mean I-V relations of I_to illustrate de-remodeling effect of SP600125 or inhibitory peptide JNKI-1 (10 (μM). JNKI-Neg, negative control peptide for JNKI-1. *p < 0.05 compared with SP600125- and JNKI-1-treated myocytes. (C) De-remodeling of I_to by p38 inhibition with SB203580 or PD169316 (10 (μM). *p < 0.05 compared with untreated MI group. I_to, transient outward K⁺ current. Numbers in parentheses represent number of myocytes sampled.