Figure 5.

The effects of rotenone, CGP37157 and kaempferol on Vm and relative [Ca²⁺]_c on uterine longitudinal smooth muscle. (A, C, E) rotenone (1 µM), CGP37157 (10 µM) and kaempferol (10 µM) all caused hyperpolarization and cessation of action potentials. (B, D, F) rotenone (1 µM) caused a sustained increase in [Ca²⁺]_c while CGP37157 (10 µM) or kaempferol (10 µM) were without effect. A high K⁺-containing (HiK) solution was transiently applied to the tissues in these experiments. [Ca²⁺]_c, cytosolic calcium; CGP37157, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one; Vm, membrane potential.