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Use-dependent block of WT NaV1.1 and R1648H channels
| Use-dependent block of peak current | Use-dependent block of persistent current | |||
|---|---|---|---|---|
| Log IC50 | k | Log IC50 | k | |
| WT NaV1.1 | −3.71 ± 0.02 (195 µM) | −0.84 ± 0.05 | ||
| R1648H | −3.86 ± 0.02 (138 µM) | −0.88 ± 0.03 | −4.51 ± 0.04 (30.9 µM) | −0.73 ± 0.05 |
