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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Gastroenterol Clin North Am. 2010 Sep;39(3):681–695. doi: 10.1016/j.gtc.2010.08.015

Table 5. Pharmacologic therapy in the prevention of recurrent variceal hemorrhage (secondary prophylaxis).

Medication Dosage Comments
Propranolol or nadolol Same as Table 3 Same as Table 3
Isosorbide mononitrate Initial: 10 mg by mouth every night

  1. Used only in combination with an NSBB

  2. Increase until maximum tolerated dose and SBP>95 mm Hg
Maximum: 20 mg twice a day

Abbreviation: SBP, systolic blood pressure.