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. 2010 Oct 12;2:859–869. doi: 10.1093/gbe/evq068

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© The Author(s) 2010. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3.— — Linear regressions of (A) the rate of nonsynonymous substitutions (dN) and (B) the rate of synonymous substitutions (dS) among panortholog families on their distance from the nearest replication origin. The dotted line depicts the linear regression function; each is statistically significant (dN: F = 179.7, P < 0.001; dS: F = 39.7, P < 0.001) despite modest explanatory power (dN: r² = 0.083; dS: r² = 0.02). Ortholog position was assigned using the Sulfolobus islandicus L.S.2.15 genome, which is justified by the high degree of synteny among the six study genomes (supplementary fig. S2, Supplementary Material online).