Table 4.
Odds ratios (95% CIs) of invasive breast cancer by estrogen receptor status, premenopausal women, New York University Women's Health Study (145 estrogen receptor–positive cases/145 controls and 52 estrogen receptor–negative cases/52 controls)
| Characteristic | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Ptrend |
|---|---|---|---|---|---|
| 2-OHE1, pg/mL | |||||
| ER+ | |||||
| Unadjusted* | 1.00 (reference) | 2.29 (1.13–4.66) | 1.66 (0.77–3.57) | 2.56 (1.11–5.89) | 0.12 |
| Adjusted† | 1.00 (reference) | 2.74 (1.17–6.41) | 1.91 (0.76–4.76) | 2.38 (0.84–6.74) | 0.41 |
| ER− | |||||
| Unadjusted* | 1.00 (reference) | 0.76 (0.24–2.38) | 0.85 (0.30–2.40) | 0.66 (0.14–3.12) | 0.66 |
| Adjusted† | 1.00 (reference) | 1.26 (0.26–6.06) | 1.02 (0.27–3.91) | 2.39 (0.25–22.49) | 0.70 |
| 16α-OHE1, pg/mL | |||||
| ER+ | |||||
| Unadjusted* | 1.00 (reference) | 1.29 (0.68–2.44) | 1.12 (0.61–2.06) | 0.83 (0.41–1.70) | 0.65 |
| Adjusted† | 1.00 (reference) | 1.21 (0.59–2.52) | 0.92 (0.45–1.90) | 0.59 (0.26–1.34) | 0.18 |
| ER− | |||||
| Unadjusted* | 1.00 (reference) | 1.91 (0.61–5.94) | 1.04 (0.33–3.33) | 1.15 (0.36–3.71) | 0.92 |
| Adjusted† | 1.00 (reference) | 2.44 (0.50–11.93) | 1.70 (0.36–7.94) | 1.38 (0.28–6.78) | 0.64 |
| 2-OHE1:16α-OHE1 ratio | |||||
| ER+ | |||||
| Unadjusted* | 1.00 (reference) | 1.24 (0.63–2.43) | 1.83 (0.91–3.66) | 2.24 (1.07–4.68) | 0.02 |
| Adjusted† | 1.00 (reference) | 1.44 (0.65–3.18) | 1.79 (0.80–4.00) | 2.15 (0.88–5.27) | 0.09 |
| ER− | |||||
| Unadjusted* | 1.00 (reference) | 1.06 (0.34–3.28) | 1.13 (0.32–4.00) | 0.62 (0.14–2.80) | 0.64 |
| Adjusted† | 1.00 (reference) | 1.12 (0.29–4.41) | 1.69 (0.34–8.40) | 1.18 (0.21–6.49) | 0.74 |
Abbrevaitions: ER+, estrogen receptor positive; ER−, estrogen receptor negative.
Conditional logistic regression (matching variables: age, date of blood donation, day and phase of menstrual cycle).
Conditional logistic regression (matching variables: age, date of blood donation, day and phase of menstrual cycle) adjusting for first-degree family history of breast cancer (negative, one affected relative ≥45 years old, one affected relative <45 years old, or more than one affected relative), ever smoking (no, yes), BMI (log2 transformation), age at menarche (log transformed), or parity/age at first full-term pregnancy (<20, 20–24, 25–29, 30+, nulliparous).