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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2010 Jan 15;18(4):1441–1448. doi: 10.1016/j.bmc.2010.01.019

Figure 4.

Figure 4

Cytoprotective effects of ω-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids 4a or 4b and 3-(2,6-dimethylphenoxy)propanoic acid 1c and 3-(2,6-dimethylphenoxy) acrylic acid 6a in isolated rat cardiomyocytes. Upper panel: Alkanoic acids 4a and 4b (1 μM), methimazole (1 μM), and etomoxir (20 μM) were incubated with cardiomyocytes in a hypoxia-reoxygenation protocol, as described in Section 5. CON, control; HR, hypoxia-reoxygenation; Eto, etomoxir. Statistical analysis (one-way ANOVA, n = 3): CON versus HR, p <.05; HR versus HR + 4a, p <.05; CON versus HR + 4a, NS; HR + 4a versus HR + 4a + Eto, p <.05; HR versus HR + 4b, p <.05; HR + 4b versus HR + 4b + Eto, p <.05; HR versus Methimazole, NS. Lower panel: Alkanoic acids 1c and 6a (1 μM), 2,6-dimethylphenol (1 μM), and etomoxir (20 μM) were incubated with cardiomyocytes in a hypoxia-reoxygenation protocol, as described in Section 5. CON, control; HR, hypoxia-reoxygenation; Eto, etoximir. Statistical analysis (one-way ANOVA, n = 3): CON versus HR, p <.05; HR versus HR + 1c, p <.05; CON versus HR + 1c, p <.05; HR + 1c versus HR + 1c + Eto, p <.05; HR versus HR + 6a, p <.05; HR + 6a versus HR + 6a + Eto, p <.05; HR versus 2,6-dimethylphenol, NS.