Table 1.

Rates of mitochondrial biotransformation of ω-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and ω-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids^a

Compound	Rate
1a	2.06 ± 0.50
1b	0.39 ± 0.12
1c	0.07 ± 0.02
1d	0.10 ± 0.06
2a	1.27 ± 0.37
2b	0.39 ± 0.12
2c	0.06 ± 0.01
2d	0.01 ± 0.06
3	1.54 ± 0.17
4a	2.50 ± 0.31
4b	0.97 ± 0.16
5	0.54 ± 0.06
6a	1.55 ± 0.14
6b	N.D.
Octanoic acid	40.3 ± 6.7

^aThe alkanoic acids (Fig. 2) were incubated with rat liver mitochondria, and product formation was quantified, as described in Section 5. Rates are expressed as nmol min⁻¹ mg protein⁻¹. Data are shown as mean ± SD, n = ≥ 3. Statistical analysis (unpaired t-test): 1a versus 2a, p <.05; 1b versus 2b, NS; 1c versus 2c, NS; 1d versus 2d, p <.05; 1a versus 3, p <.05; 2a versus 3, p >.05; 1c versus 5, p <.05; 1c versus 6a, p <0.05; 2c versus 5, p <.05; 1a versus 6a, p <.05. N.D., not detected.