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. 2010 Dec 10;5(12):e14272. doi: 10.1371/journal.pone.0014272

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Baum et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Every circle represents one of the seven profiled compounds. The size of each circle corresponds to the number of off-target genes (in red). On-target genes numbers are shown in blue. B: Ingenuity pathway analysis for the off-target genes of all seven NCEs after 12 hours: Clustering of the -log10[p-values] using complete linkage and manhattan distance depicts the 51 significantly ranked canonical signaling pathways. Off target genes deregulated by BI3 treatment affect almost exclusively 10 cancer signaling pathways (red arrows). Ex1 & Ex2 off-target genes play a role in 12 pathways involved in cytotoxicity or cell death (grey arrows) and in five pathways involved in inflammation (green arrows). The color code defines the significance determined by Fisher's exact test as –log10[p-value]: blue <2 – not significant; white = 2 – significant & red >2 – highly significant.