Table 2. Statistics of relative rate test between subfamilies of CYP3 in Actinopterygii.

Subfamily 1/Subfamily 2	K1	K2	dK	sd_dK	Ratio	P
CYP3A/CYP3B	0.56	0.79	−0.23	0.06	−3.55	0.00039*
CYP3A/CYP3C	0.56	0.65	−0.09	0.06	−1.56	0.11810*
CYP3A/CYP3D	0.56	0.93	−0.37	0.07	−5.25	3.63E-07*
CYP3B/CYP3C	0.79	0.65	0.13	0.06	2.12	0.03442*
CYP3B/CYP3D	0.79	0.93	−0.14	0.08	−1.70	0.08878*

K1 (K2): the mean values of amino acid substitution rate between Subfamily 1 (Subfamily 2) and outgroup. dK: difference between K1 and K2. sd_dK: standard deviation. Ratio: the dK-to-sd_dK ratio. P: p value for each test. The significant tests at 5% cutoff after Bonferroni correction are labeled with *.