Table 2.
L. plantarum genes with putative roles in modulating PBMC cytokine production.
| Genes(s) | Gene numbera | Product | Percent of strains with the gene(s)b | Gene-dependent contribution to cytokine stimulationc | |
|---|---|---|---|---|---|
| lp_1953 | lp_1953 | Hypothetical protein | 48 | IL-10 | 1.6-fold ↑ |
| pts19ADCBR | lp_2647-2651 | N-galactosamine PTS, EIIADCB and transcription regulator, GntR family | 33 | IL-10 | 1.7-fold ↓ |
| plnEFI | lp_0419-0422 | Immunity protein PlnI | 81-85 | IL-10/IL-12 | 1.7-fold ↓ |
| Bacteriocin-like peptide PlnF | |||||
| Bacteriocin-like peptide PlnE | |||||
| plnG | lp_0423 | ABC transporter | 88 | IL-10/IL-12 | 1.8-fold ↓ |
| lamB | lp_3582 | Accessory gene regulator protein | 43 | IL-10/IL-12 | 1.3-fold ↓ |
| prophage P2b 1 & 21 | lp_2460 | Prophage P2b protein 21 | 38 | IL-10/IL-12 | 1.5-fold ↑ |
| lp_2480 | Prophage P2b protein 1, integrase | ||||
a Gene number on the L. plantarum WCFS1 chromosome [23].
b Percentage of L. plantarum strains containing the gene according to CGH [27,28].
c Gene-trait matching importance measures (in parentheses) and predicted effects of the gene(s) on the variable and average magnitude and direction (higher or lower) of IL-10 and IL-10/IL-12 amounts.