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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Curr Opin Pharmacol. 2010 Jan 14;10(2):146–155. doi: 10.1016/j.coph.2009.12.001

Table 2.

Functional phenotype of genetic deletion mutant mice against PIAS and SENP [9,37•].

Modulator Classification Phenotypic effects of genetic mutation Ref
PIAS1 E3 ligase Systemic PIAS1−/− susceptible against viral and microviral infection, high level of NF-κB and STAT1 transcriptional activity [40]
PIAS4 E3 ligase Systemic PIAS4−/− no developmental defect, susceptible against septic-shock [41 ,43•]
SENP1 deconjugase Systemic SENP1−/− embryonic lethal and defect in erythropoiesis [52,53•]
SENP2 deconjugase Systemic SENP2−/− embryonic lethal and defect in cell cycle G1-S transition [54•]