. Author manuscript; available in PMC: 2011 Jul 16.

Published in final edited form as: Cleft Palate Craniofac J. 2010 Jul 1;48(4):363–370. doi: 10.1597/09-227

Table 4.

Association of CRISPLD2 and NS CL(P): Results of chi-square analysis on total Brazilian case-control sample and TDT analysis in families from multiple populations

	Case- Control (χ² p- value)	p-values from family-based TDT for CL(P)^a
		UNITED STATES
	BRAZIL	Texas^b		Total USA^c	ASIA		EUROPE			CENTRAL AMERICA	SOUTH AMERICA
Ethnicity	Cauc.	Cauc	Hisp	Cauc	Phil	China	Spain	Hungary	Turkey	Guatemala	ECLAMC^d
Number of Families	n/a	262	82	532	204	84	39	31	40	95	224
SNP:
rs1546124	*0.04*	*0.01*	0.53	*0.02*	0.37	0.27	0.87	n/a	0.09	0.98	0.30
rs8061351	*0.04*	0.76	*0.02*	0.85	0.40	0.59	0.27	0.85	0.76	0.43	---
rs2326398	0.11	0.19	0.06	0.20	0.24	0.16	0.83	n/a	0.10	0.19	0.43
rs4783099	1.00	0.17	0.22	0.54	0.80	0.90	0.41	0.68	0.13	0.89	---

n/a = not applicable because not enough informative families; Cauc=Caucasian ethinicity, Hisp=Hispanic, Phil=the Philippines

p-values from FBAT analysis of families, values in bold italics reach nominal significance (ie p-value<0.05), values in bold are suggestive (0.05<p-value<0.10).

Results from original CRISPLD2 report (Chiquet et al., 2007)

“Total USA Cauc” includes Pittsburgh, St. Louis, Iowa and Texas-Caucasian

ECLAMC families were not genotyped for rs8061351 and rs4783099