Table 4.
Case- Control (χ2 p- value) | p-values from family-based TDT for CL(P)a | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
UNITED STATES | |||||||||||
BRAZIL | Texasb | Total USAc | ASIA | EUROPE | CENTRAL AMERICA | SOUTH AMERICA | |||||
Ethnicity | Cauc. | Cauc | Hisp | Cauc | Phil | China | Spain | Hungary | Turkey | Guatemala | ECLAMCd |
Number of Families | n/a | 262 | 82 | 532 | 204 | 84 | 39 | 31 | 40 | 95 | 224 |
SNP: | |||||||||||
rs1546124 | 0.04 | 0.01 | 0.53 | 0.02 | 0.37 | 0.27 | 0.87 | n/a | 0.09 | 0.98 | 0.30 |
rs8061351 | 0.04 | 0.76 | 0.02 | 0.85 | 0.40 | 0.59 | 0.27 | 0.85 | 0.76 | 0.43 | --- |
rs2326398 | 0.11 | 0.19 | 0.06 | 0.20 | 0.24 | 0.16 | 0.83 | n/a | 0.10 | 0.19 | 0.43 |
rs4783099 | 1.00 | 0.17 | 0.22 | 0.54 | 0.80 | 0.90 | 0.41 | 0.68 | 0.13 | 0.89 | --- |
n/a = not applicable because not enough informative families; Cauc=Caucasian ethinicity, Hisp=Hispanic, Phil=the Philippines
p-values from FBAT analysis of families, values in bold italics reach nominal significance (ie p-value<0.05), values in bold are suggestive (0.05<p-value<0.10).
Results from original CRISPLD2 report (Chiquet et al., 2007)
“Total USA Cauc” includes Pittsburgh, St. Louis, Iowa and Texas-Caucasian
ECLAMC families were not genotyped for rs8061351 and rs4783099