Table 1.

Fourteen SNPs associated with WHR at genome-wide significance levels

SNP	Chr	Position (b36)	Nearby genes	EA a	EAFb	Discovery			Follow-up			Combined
						P	Beta	N	P	Beta	N	P	Beta
SNPs evaluated in follow-up achieving genome-wide significance
rs9491696	6	127,494,332	RSPO3	G	0.520	2.10E-14	0.037	77,164	3.27E-28	0.045	113,582	1.84E-40	0.042
rs6905288	6	43,866,851	VEGFA	A	0.562	4.72E-10	0.033	77,129	1.18E-16	0.039	95,430	5.88E-25	0.036
rs984222	1	119,305,366	TBX15-WARS2	G	0.365	3.81E-14	0.037	77,167	1.56E-12	0.031	109,623	8.69E-25	0.034
rs1055144	7	25,837,634	NFE2L3	T	0.210	1.49E-08	0.034	77,145	3.26E-18	0.043	113,636	9.97E-25	0.040
rs10195252	2	165,221,337	GRB14	T	0.599	3.23E-10	0.031	77,119	3.18E-16	0.036	102,449	2.09E-24	0.033
rs4846567	1	217,817,340	LYPLAL1	G	0.283	2.37E-12	0.037	77,167	3.15E-10	0.032	91,820	6.89E-21	0.034
rs1011731	1	170,613,171	DNM3-PIGC	G	0.572	1.72E-10	0.031	77,094	7.47E-09	0.026	92,018	9.51E-18	0.028
rs718314	12	26,344,550	ITPR2-SSPN	G	0.741	2.41E-08	0.031	77,167	1.49E-10	0.030	107,503	1.14E-17	0.030
rs1294421	6	6,688,148	LY86	G	0.387	6.31E-09	0.029	77,154	2.69E-10	0.028	102,189	1.75E-17	0.028
rs1443512	12	52,628,951	HOXC13	A	0.239	3.33E-08	0.031	77,165	2.92E-10	0.030	112,353	6.38E-17	0.031
rs6795735	3	64,680,405	ADAMTS9	C	0.406	2.47E-07	0.025	77,162	6.75E-08	0.026	84,480	9.79E-14	0.025
rs4823006	22	27,781,671	ZNRF3-KREMEN1	A	0.569	4.47E-08	0.027	77,086	2.41E-05	0.019	93,911	1.10E-11	0.023
rs6784615	3	52,481,466	NISCH-STAB1	T	0.941	3.18E-07	0.052	76,859	1.56E-04	0.036	109,028	3.84E-10	0.043
rs6861681	5	173,295,064	CPEB4	A	0.340	1.40E-06	0.026	77,164	2.13E-04	0.019	85,722	1.91E-09	0.022
Further SNPs evaluated in follow-up but not achieving genome-wide significant in the combined analysis
rs2076529	6	32,471,933	BTNL2	C	0.570	2.22E-08	0.041	34,532	0.012	0.011	92,778	3.71E-07	0.020
rs7081678	10	32,030,629	ZEB1	A	0.085	5.76E-07	0.045	76,270	0.094	0.013	100,527	5.57E-06	0.027

P-values and beta-coefficients (per change of WHR increasing allele) for the association with WHR on the inverse normal transformed ranked scale in the meta-analyses of discovery studies (up to 77,167), follow-up studies (up to 113,636 subjects), and both combined (up to 190,781 subjects). Fourteen of the 16 SNPs put forward to follow-up show genome-wide significant results (P < 5 × 10⁻⁸) in the combined analysis. P-values in the discovery were genomic control corrected per study and in the meta-analysis. Details on between-study heterogeneity in Supplementary Table 1c.

^aEffect Allele: WHR increasing allele on the forward strand;

^bEffect allele frequency