Table 2.
Evidence of sex-differences in the WHR association at seven of the 14 associated loci
| SNP | Nearby Genes |
Men | Women | Sex difference |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Discovery | Follow-up | Combined | Discovery | Follow-up | Combined | Com- bined |
||||||||
| P | Beta | P | Beta | P | Beta | P | Beta | P | Beta | P | Beta | P | ||
| rs9491696 | RSPO3 | 1.68E-04 | 0.026 | 6.97E-09 | 0.036 | 1.05E-11 | 0.031 | 1.62E-12 | 0.047 | 8.84E-22 | 0.053 | 1.93E-32 | 0.050 | 1.94E-03 |
| rs6905288 | VEGFA | 0.066 | 0.013 | 2.09E-04 | 0.025 | 7.38E-05 | 0.020 | 7.72E-13 | 0.052 | 3.14E-15 | 0.051 | 2.27E-26 | 0.052 | 5.20E-06 |
| rs984222 | TBX15-WARS2 | 3.32E-09 | 0.041 | 2.43E-05 | 0.029 | 9.41E-13 | 0.035 | 1.21E-07 | 0.036 | 1.33E-08 | 0.033 | 1.02E-14 | 0.034 | 0.951 |
| rs1055144 | NFE2L3 | 6.00E-04 | 0.029 | 5.67E-08 | 0.040 | 2.52E-10 | 0.035 | 2.34E-06 | 0.040 | 7.13E-12 | 0.046 | 1.41E-16 | 0.044 | 0.270 |
| rs10195252 | GRB14 | 0.201 | 0.009 | 0.114 | 0.011 | 0.043 | 0.010 | 6.33E-15 | 0.053 | 4.95E-21 | 0.054 | 3.84E-34 | 0.054 | 1.41E-11 |
| rs4846567 | LYPLAL1 | 0.191 | 0.010 | 0.982 | 0.000 | 0.358 | 0.005 | 4.84E-18 | 0.064 | 8.12E-17 | 0.055 | 4.95E-33 | 0.059 | 1.18E-13 |
| rs1011731 | DNM3-PIGC | 4.88E-07 | 0.034 | 1.95E-03 | 0.022 | 7.81E-09 | 0.028 | 2.13E-05 | 0.028 | 7.03E-07 | 0.030 | 6.90E-11 | 0.029 | 0.855 |
| rs718314 | ITPR2-SSPN | 0.177 | 0.010 | 2.02E-03 | 0.022 | 1.41E-03 | 0.017 | 8.29E-10 | 0.047 | 4.21E-09 | 0.038 | 2.41E-17 | 0.042 | 4.67E-04 |
| rs1294421 | LY86 | 4.18E-03 | 0.020 | 7.00E-06 | 0.030 | 1.63E-07 | 0.025 | 3.44E-08 | 0.038 | 7.32E-06 | 0.026 | 2.40E-12 | 0.031 | 0.357 |
| rs1443512 | HOXC13 | 0.184 | 0.011 | 9.74E-04 | 0.024 | 9.45E-04 | 0.018 | 1.43E-09 | 0.048 | 3.09E-08 | 0.035 | 6.38E-16 | 0.040 | 2.23E-03 |
| rs6795735 | ADAMTS9 | 0.011 | 0.017 | 0.614 | 0.004 | 0.027 | 0.011 | 7.85E-07 | 0.033 | 2.95E-11 | 0.042 | 1.92E-16 | 0.038 | 8.50E-05 |
| rs4823006 | ZNRF3-KREMEN1 | 6.87E-03 | 0.019 | 0.094 | 0.012 | 1.94E-03 | 0.015 | 6.86E-08 | 0.037 | 3.81E-05 | 0.024 | 3.24E-11 | 0.030 | 0.032 |
| rs6784615 | NISCH-STAB1 | 1.51E-03 | 0.045 | 0.033 | 0.032 | 1.68E-04 | 0.039 | 6.23E-05 | 0.057 | 1.72E-03 | 0.039 | 6.01E-07 | 0.047 | 0.574 |
| rs6861681 | CPEB4 | 1.88E-03 | 0.023 | 0.045 | 0.015 | 3.03E-04 | 0.019 | 2.14E-04 | 0.027 | 1.58E-03 | 0.021 | 1.55E-06 | 0.024 | 0.555 |
P-values and beta-coefficients (per change of WHR increasing allele in the sex-combined analysis as in Table 1) for the WHR association are given for the discovery (up to 34,601 men, 42,735 women), the follow-up (up to 47,882 men, 65,780 women) and the combined meta-analysis (up to 81,301 men, 107,429 women). Also given are the P-values for testing for difference between sex-specific beta-coefficients in the combined meta-analysis; SNPs with P for sex difference < 3.6E-03 (=0.05/14) were considered to show significant sex difference.