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. 2010 Oct 12;285(51):39597–39608. doi: 10.1074/jbc.M110.129718

FIGURE 7.

FIGURE 7.

Expression of the ubiquitin ligases, Atrogin-1/MAFbx and MuRF1, and the E2, E2–14K, does not increase in muscles of aged animals and cannot be induced by dexamethasone. Real time PCR analysis of mRNAs encoding Atrogin-1/MAFbx and MuRF1, and the E2 ubiquitin conjugating enzyme E2-14K. A, muscle expression in 4-month and 30-month-old rats fed AL (AL) or DR. B, expression in muscle in 4-month and 30-month-old AL rats treated with dexamethasone and age-matched controls. Individual samples were run in triplicates and expressed relative to adult control samples. Error bars are S.E. **, p < 0.01; ***, p < 0.001.