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. 2010 Oct 11;285(51):39623–39636. doi: 10.1074/jbc.M110.140467

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Knockdown of dHCF in vivo impairs (Myc-dependent) growth. A, expression of dHCF-dsRNA in bristle precursor cells with sca-GAL4 reduces the average area of posterior scutellar bristles (n = 6, 7, 4, for control, hcf2, hcf3, respectively); the size reduction is borderline significant (p = 0.06 for both hcf-samples as compared with control). B, knockdown of dHCF alleviates wing defects caused by Myc overexpression under the control of ap-GAL4. Adult Myc-overexpressing wings were assigned to the phenotypic classes shown in the top panel, according to their appearance under a dissecting microscope (n = 21 for control and 25 for each of the dHCF samples). C, average area of salivary gland nuclei that have been overexpressing Myc and/or dHCF-dsRNA for 45 h (n = 34–48). D, expression of dHCF-dsRNA during eye development significantly reduces the area of dm^P0 (hypomorphic Myc-mutant) ommatidia, but not of wild-type ommatidia (n = 4–7). * and ** indicate that comparisons with the corresponding control genotype (without dHCF-RNAi) are significant with p < 0.05 and p < 0.01, respectively.

FIGURE 3. — Knockdown of dHCF in vivo impairs (Myc-dependent) growth. A, expression of dHCF-dsRNA in bristle precursor cells with sca-GAL4 reduces the average area of posterior scutellar bristles (n = 6, 7, 4, for control, hcf2, hcf3, respectively); the size reduction is borderline significant (p = 0.06 for both hcf-samples as compared with control). B, knockdown of dHCF alleviates wing defects caused by Myc overexpression under the control of ap-GAL4. Adult Myc-overexpressing wings were assigned to the phenotypic classes shown in the top panel, according to their appearance under a dissecting microscope (n = 21 for control and 25 for each of the dHCF samples). C, average area of salivary gland nuclei that have been overexpressing Myc and/or dHCF-dsRNA for 45 h (n = 34–48). D, expression of dHCF-dsRNA during eye development significantly reduces the area of dm^P0 (hypomorphic Myc-mutant) ommatidia, but not of wild-type ommatidia (n = 4–7). * and ** indicate that comparisons with the corresponding control genotype (without dHCF-RNAi) are significant with p < 0.05 and p < 0.01, respectively.