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Human CTRP3A or CTRP3B suppresses gluconeogenesis in vitro. Glucose production was reduced in rat H4IIE hepatoma cells treated with 5 μg/ml recombinant human CTRP3A or CTRP3B for 16 h (A). Human CTRP3 treatment also suppressed the expression of gluconeogenic genes PEPCK and G6Pase (B). Each bar represents the mean ± S.E. (error bars) (n = 5). *, p < 0.05.
