Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
I/R induces release of acetylated-HMGB1 from hepatocytes through HDAC1 deactivation and HDAC4 shuttling. The proposed model showing release of acetylated HMGB1 following I/R. Both de-activation of nuclear HDAC1 and cytosplasmic shuttling of HDAC4 contribute to a reduction in overall nuclear HDAC activity, tilting the acetylation/deacetylation balance of HMGB1 toward net acetylation and release.
