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. 2010 Oct 12;285(51):40114–40124. doi: 10.1074/jbc.M110.156729

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Activation of TCPTP in integrin α1-null mesangial cells is sufficient to decrease caveolin-1 phosphorylation. A, integrin α1-null mesangial cells either overexpressing (α1KO-TCPTP) or not overexpressing (α1Ko-Vo) full-length TCPTP were analyzed by Western blot for levels of total and phosphorylated Cav-1 (20 μg/lane). Cav-1 and pCav-1 bands were quantified by densitometry analysis, and the pCav-1 signal is expressed as a pCav-1/Cav-1 ratio. Values are the mean ± S.D. of four clones (only two shown) and represent -fold changes relative to untransfected cells (α1KO). B, integrin α1-null mesangial cells were incubated for 18 h with spermidine at the concentrations indicated, and total cell lysates (20 μg/lane) were analyzed by Western blot for levels of total and phosphorylated Cav-1.