TABLE 4.

Effect of NC-005-pvs and NC-005 on cathepsin activity in HeLa S3 cells

Hydrolysis of pan-cathepsin substrate Z-FR-amc by acidic extracts of cytosol-depleted cells was measured after 6 h of treatment of cells with inhibitors. Values are averages ± S.E. of three independent measurements for NC-005-pvs; results of single measurement for NC-005 are shown.

Concentration	Inhibitor
	NC-005-pvs	NC-005
μm	cathepsin activity (% control)
0.1	82 ± 42	77
0.33	58 ± 24	93
1	37 ± 10	85
3	15 ± 2	93
9	13 ± 3