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. 2010 Oct 14;285(51):40180–40191. doi: 10.1074/jbc.M110.142356

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Involvement of choline in galantamine-enhanced microglial Aβ phagocytosis. A, rat microglia were cultured in the presence or absence of 28 μm choline and treated with 1 μm Aβ42 plus 1 μm galantamine, or 1 μm Aβ42 plus 1 mm nicotine. The amount of Aβ42 phagocytosed by microglia was measured by ELISA. *, p < 0.05; **, p < 0.01 versus Aβ42 alone in choline-free culture medium. §, p < 0.05; §§, p < 0.01 versus Aβ42 alone in choline-containing culture medium. ††, p < 0.01 versus Aβ42 plus galantamine in choline-containing culture medium. Cho, choline; Gal, galantamine; Nic, nicotine. The data represent the means ± S.E. of seven samples in each group. B, concentration-dependent curves of the choline effect on microglial Aβ phagocytosis were investigated. The data represent the means ± S.E. of 4–13 samples in each group. C, concentration-dependent curves of the nicotine effect on microglial Aβ phagocytosis were investigated in the absence of choline. The data represent the means ± S.E. of 3–7 samples in each group.