TABLE 3.
Hazard Ratios and Risk Ratios for Each Drug Compared to Referent, as Found in Different Types of Analyses
| TPM = REFERENT |
CBZ = REFERENT |
||||
|---|---|---|---|---|---|
| DRUG: | CRUDE HR* | SEX AND AGE ADJUSTED HR* | FULLY ADJUSTED HR* | PROPENSITY-MATCHED RR† | PROPENSITY-MATCHED RR‡ |
| CBZ | 1.22 | 1.38 | 1.24 | 1.08 | - |
| GBP | 0.95 | 1.48 | 1.42§ | 1.99 | 1.45 |
| LTG | 3.90 | 3.58 | 1.84§ | 1.31 | 0.97 |
| LVT | 1.34 | 1.57 | 1.63 | 0.62 | 1.10 |
| OXC | 4.60 | 3.88 | 2.07§ | 1.49 | 1.41 |
| PB | 1.24 | 1.54 | 0.99 | 1.64 | 1.12 |
| PHT | 0.94 | 1.23 | 1.25 | 1.44 | 2.62 |
| PGB | 0.63 | 1.30 | 1.18 | 0.88 | 0.63 |
| PMD | 0.51 | 1.08 | 1.15 | 1.02 | 0.98 |
| TGB | 3.88 | 4.38 | 2.41§ | 1.98 | 1.23 |
| TPM | - | - | - | - | 0.80 |
| VPA | 3.33 | 3.11 | 1.65§ | 0.84 | 1.02 |
| ZNM | 1.09 | 1.16 | 1.25 | 3.73 | 0.97 |
*
From TABLE 4 in Patorno et al. (29).
†
RR, relative risk; from e-table 6 (results for “as treated within 180 days”) in Patorno et al. (29).
‡
RR, relative risk; from e-table 9 (results for “as treated within 180 days”) in Patorno et al. (29).
§
Interpreted by Patorno et al. (29) as possibly posing an increased risk for suicidality.
Abbreviations: CBZ, carbamazepine; GBP, gabapentin; LTG, lamotrigine; LVT, levetiracetam; OXC, oxcarbazepine; PB, phenobarbital; PHT, phenytoin; PGB, pregabalin; PMD, primidone; TGB, tiagabine; TPM, topiramate; VPA, valproic acid; ZNM, zonisamide.