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. 2010 Aug 6;38(22):8083–8094. doi: 10.1093/nar/gkq649

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Comparative analysis of XPA and RPA binding to damaged and undamaged DNA. Increasing amounts of XPA (A) or RPA (B) were added to undamaged DNA duplex (lanes 1–5), damaged DNA duplex (lanes 6–10), undamaged DNA duplex with 15 nt bubble (lanes 11–15), or damaged bubble (lanes 16–20). A 5-fold excess of non-radioactive native 48-mer duplex was added in the reaction mixtures to compete binding of the studied DNA structures with XPA (C) or RPA (D). The right panels show quantitative analysis from the A, B,C and D experiments. Bars indicate error of five independent sets of experiments.