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. 2010 Aug 6;38(22):8277–8283. doi: 10.1093/nar/gkq650

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic representation of frameshift reporter constructs. ORF1 (19 kD) is in the 0 frame and ORF2 (46 kD) is in the −1 translational frame with respect to ORF1. The appearance of the 65 kD fusion protein represents the occurrence of −1 frameshifting. The UUUAAAC slippery sequence is indicated in italics. The 0-reading frame and −1 reading frames codons are indicated above and below the sequences, respectively. RNA18, 12, 15, 9 and 6 are antisense RNA oligonucleotides complementary to the indicated region downstream of the slippery sequence in SF468 mRNA.