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Secondary structure representations of (A) Eco, (B) Mth, (C) Mja and (D) Hsa RPRs (12,15). Letters indicate universally conserved nucleotides (12). Paired helices (e.g. P1, P2) are numbered consecutively from 5′ to 3′ and according to the Eco RPR nomenclature (12). Alternative secondary structure representations (69) are provided in Supplementary Figure S1.
