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. 2010 Sep 29;38(22):e198. doi: 10.1093/nar/gkq860

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Tyrosinase (Tyr) knockdown mouse. (A) The artificial miRNA for Tyr was expressed under the control of the CAG promoter at the Rosa26 locus (Rosa26^CAG::miR-^Tyr). (B) The levels of Tyr mRNA were quantitated by real-time RT-PCR analysis. Coat color (A), melanin in ears (C) and choroid coat (D) were compared between the wild-type and Rosa26^CAG::miR-^Tyr mice.