Table 4.
Immunoglobulin G subclass contents of plasma pools collected from Group I, II, III and IV donors
| Donors |
||||
|---|---|---|---|---|
| IgG subclass (g/l) | Group In = 51 | Group IIn = 5 | Group IIIn = 8 | Group IVn = 41 |
| IgG1 | 4·67 ± 0·63b | 5·01 ± 0·11 | 3·66 ± 0·60 | 3·40 ± 0·66 |
| % Variationa | +7% | −22% | −27% | |
| P-value | > 0·05 | < 0·0001 | < 0·0001 | |
| IgG2 | 2·57 ± 0·22 | 2·66 ± 0·06 | 2·14 ± 0·19 | 1·80 ± 0·17 |
| % Variation | +3% | −17% | −30% | |
| P-value | > 0·05 | < 0·0001 | < 0·0001 | |
| IgG3 | 0·34 ± 0·03 | 0·32 ± 0·03 | 0·31 ± 0·03 | 0·31 ± 0·02 |
| % Variation | −5% | −8% | −8% | |
| P-value | > 0·05 | < 0·05 | < 0·0001 | |
| IgG4 | 0·46 ± 0·05 | 0·45 ± 0·02 | 0·44 ± 0·03 | 0·34 ± 0·03 |
| % Variation | −1% | −2% | −26% | |
| P-value | > 0·05 | > 0·05 | < 0·0001 | |
IgG subclass levels were determined in Group II (n = 5), Group III (n = 8), and Group IV (n = 41) plasma pools and compared with those of Group I plasma pools (n = 51).
a
Percent variations with respect to Group I donation pool values taken as 100%.
b
The results are means of the tested batches ± SD. IgG subclass contents were measured by nephelometry. P < 0·0001 is considered highly significant.