Table 4.
Similarities between SGs and unfolded protein aggregates. SGs and aggresomes share components and their assembly is mechanistically linked, suggesting a role for SGs in unfolded protein diseases (see text).
| Stress Granules | Unfolded protein aggregates |
|---|---|
| Similarities | |
| Induced by several stressors | Present in several pathologies (ER-stress and/or oxidative stress involved) [208] |
| Induced by proteasome or autophagy inhibitors | Dissolution requires proteosome activity or autophagy. [209] |
| Aggregation modulated by HSP70 | Miss-folded protein aggregation modulated by chaperones. |
| Contain ubiquitinated proteins | Contain ubiquitinated proteins. [210], [211] |
| Contain O-glycosilated proteins | Contain O-glycosilated proteins [212] |
| Microtubule and dynein-dependent | Microtubule and dynein-dependent. [213], [214] |
| Differences | |
| Highly dynamic | Quite static [214] |
| Transient | Long-lived |
| Protective | Pathogenic or protective |