|
Antidepressants and antipsychotics |
|
Enzyme inhibition leading to increased serum concentrations of AEDs |
Haloperidol, risperidone |
Carbamazepine |
|
Chlorpromazine |
Valproic acid |
|
Clomipramine |
Carbamazepine, phenytoin, phenobarbital, valproic acid |
|
Sertraline |
Carbamazepine, lamotrigine, phenytoin, valproic acid, |
|
|
Oral contraceptives |
Lamotrigine, valproic acid (oxcarbazepine?) |
Induction of metabolism (glucuronidation) and reduced serum concentrations of AEDs |
|
Antimicrobal drugs |
|
Enzyme inhibition by antimicrobal drugs leading to
increased serum concentrations of AEDs |
Macrolides (clarithromycin,
erythromycin, troleandomycin) |
Carbamazepine |
|
Rifampicin |
Lamotrigine |
|
Isoniazid |
Carbamazepine, ethosuximide, phenytoin, valproic acid |
|
|
Others |
|
Probenicid |
Carbamazepine |
Induction of metabolism and reduced serum
concentrations of carbamazepine |
|
|
|
Antacides |
Gabapentin |
Decreased absorption of gabapentin |
Cimetidine |
|
Reduction in excretion of gabapentin leading to a
prolonged half-life |
|
Salicylates and naproxene |
Tiagabine |
Displacement of tiagabine from plasma proteins leading
to a decrease in the total serum concentration of
tiagabine but unchanged free concentration |
|
|