. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: Expert Opin Biol Ther. 2010 Jan;10(1):29–41. doi: 10.1517/14712590903321462

Table 1.

Comparison of major viral vector systems for cardiovascular gene transfer.

Vectors	Adenovirus	Adeno-Associated Virus
Functional titer (per ml)	Up to 10¹²	Up to 10¹⁰
Genome	dsDNA	ssDNA (can also be dsDNA)
Insert Capacity	7–30 kb	4.8 kb
Integration	No	Yes:chromosome 19 for wild-type AAV2 Low for recombinant vectors
Pattern of gene expression	Transient	Long-term
Cell cycle-dependent transduction	No	No
Immunoreactions	Cytotoxic and immunogenic	Minimally immunogenic
Clinical trial approved	Yes	Yes