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. Author manuscript; available in PMC: 2010 Dec 13.
Published in final edited form as: Methods Enzymol. 2009;467:461–497. doi: 10.1016/S0076-6879(09)67018-X

Figure 4. Single-tissue compartmental model.

Figure 4

Simulation of three targeted strategies of blocking NRP1 functionality: (A) NRP1 expression; (B) VEGF-NRP1 binding; (C) VEGFR-NRP1 coupling. D, Inhibition of VEGF-VEGFR2 signaling by increasing doses of each of the three strategies outlined in A–C. Peak and average over the first 48 hours following therapeutic administration. Sample results (D) based on data previously published in (Mac Gabhann and Popel, 2006).