TABLE 3.

Basal metabolism and oGTT in male and female offspring of rats fed CON or MD diet during the peri-conception period at 26 and 51 wk of age¹

	26 wk				51 wk
	Female		Male		Male		Significance2
	CON	MD	CON	MD	CON	MD	A3	S4	D	A × D3	S × D4
Plasma glucose, mmol/L5	6.0 ± 0.2	6.3 ± 0.2	6.1 ± 0.2	6.5 ± 0.2	6.6 ± 0.2	6.9 ± 0.2	0.088	—	—	—	—
Plasma insulin, nmol/L5	0.11 ± 0.02	0.13 ± 0.02	0.16 ± 0.02	0.21 ± 0.02	0.19 ± 0.02	0.25 ± 0.02	0.095	<0.001	0.019	—	—
tAUC glucose, mol/L⋅2h	1.10 ± 0.03	1.13 ± 0.03	1.14 ± 0.03	1.12 ± 0.03	1.09 ± 0.04	1.17 ± 0.04	—	—	—	0.051	—
tAUC insulin, nmol/L⋅2h	41.1 ± 5.0	39.6 ± 4.8	66.8 ± 4.7	83.0 ± 4.7	67.7 ± 6.5	64.8 ± 6.2	0.052	<0.001	—	0.070	0.028

¹Values are predicted means ± SEM, = 12–16 (1 pup/litter for each sex and age). Abbreviations: A, Age; S, Sex, and D, Dietary treatment.

²Where no value is shown, > 0.1.

³Age comparisons and A×D interactions pertain to male offspring only.

⁴Sex comparisons and S×D interactions pertain to 26-wk-old offspring only.

⁵Following overnight food deprivation.