TABLE 2.
SIX-MINUTE-WALK DISTANCE AND PULMONARY HEMODYNAMICS AT BASELINE AND END OF STUDY AFTER IMATINIB AND PLACEBO THERAPY IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION
| Imatinib |
Placebo |
|||
|---|---|---|---|---|
| Patients (n) | Absolute Value | Patients (n) | Absolute Value | |
| 6MWD, m (SD) | ||||
| Baseline | 28 | 392 (89) | 29* | 369 (118) |
| Study end | 21 | 419 (85) | 22 | 399 (86) |
| PAPm, mm Hg (SD) | ||||
| Baseline | 27 | 62 (16) | 28 | 59 (12) |
| Study end | 20 | 53 (11) | 22 | 56 (12) |
| CO, L/min (SD) | ||||
| Baseline | 27 | 4.2 (1.3) | 28 | 4.1 (1.4) |
| Study end | 20 | 4.9 (1.2) | 22 | 4.4 (1.6) |
| PVR, dynes · s · cm−5(SD) | ||||
| Baseline | 27 | 1,124 (460) | 27 | 1,118 (487) |
| Study end | 19 | 730 (230) | 21 | 1,017 (369) |
Definition of abbreviations: 6MWD = 6-minute-walk distance; CO = cardiac output; PAPm = mean pulmonary artery pressure; PVR = pulmonary vascular resistance.
*
Baseline data were missing for two patients.