Skip to main content
. 2010 Jul 9;182(10):1239–1250. doi: 10.1164/rccm.200909-1361OC

Figure 2.

Figure 2.

(A, D) Growth and(B, C, E) survival at Day 10 after early concurrent treatment (n = 12, shaded bars; A, B) and after late treatment and recovery (n = 8; D, E) on Days 9 (open bars) and 18 (solid bars) in room air (RA) and age-matched O2-exposed pups (O2) daily injected with either saline, apelin, Nω-nitro-l-arginine methyl ester (l-NAME), or a combination of apelin and l-NAME. Kaplan-Meier survival curve of apelin-treated rat pups (solid circles), age-matched O2-exposed control pups (open triangles) and RA-exposed control pups (open squares) during the first 14 days after birth (n = 12; C). Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus age-matched O2-exposed control pups. ΔP < 0.05, ΔΔP < 0.01, ΔΔΔP < 0.001 versus own room air–exposed control pups. $P < 0.05 and $$$P < 0.001 versus apelin-treated O2 pups. δδδP < 0.001 versus own treatment control pups in hyperoxic period. nd = not determined.