Figure 9.
Relative mRNA expression in (A–C) the right ventricle (RV) and (D–F) left ventricle and interventricular septum (LV+S) after early concurrent treatment of (A, D) apelin, (B, E) APJ, and (C, F) brain natriuretic peptide (BNP) in room air–exposed control pups (RA) and age-matched O2-exposed control pups (O2) daily injected with either saline, apelin, Nω-nitro-l-arginine methyl ester (l-NAME), or a combination of apelin and l-NAME. Data are expressed as mean ± SEM (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001 versus age-matched O2-exposed control pups. ΔΔP < 0.01, ΔΔΔP < 0.001 versus own room air–exposed control pups. $P < 0.05, $$P < 0.01, $$$P < 0.001 versus apelin-treated O2 pups.
