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. 2010 Jul 9;182(10):1321–1329. doi: 10.1164/rccm.200912-1884OC

Figure 4.

Figure 4.

5-HT terminal varicosities are more numerous in the XII nucleus in chronic intermittent hypoxia (CIH)- than sham-treated rats. (A, B) High-magnification images showing XII motoneurons retrogradely labeled from the base of the tongue (brown) and terminal fibers and varicosities immunostained for serotonin (5-HT) (black) in a pair of sections matched for anteroposterior (A-P) level from a CIH- and a sham-exposed rat. (C) Relationship between the numbers of 5-HT–positive terminals counted in CIH- versus sham-treated rats for 24 matched for A-P level pairs of brain sections obtained from eight pairs of CIH/sham-treated rats. For most pairs of sections (17/24), more terminal varicosities were counted in the section from a CIH rat than in the corresponding section from a sham-treated rat (data points above the identity line). The average number of 5-HT terminals was significantly higher in CIH- than sham-treated rats (603 ± 37 vs. 503 ± 31 per counting box; P = 0.012, paired t test).