Table 1. Gene expression changes in human skin fibroblasts exposed to chronic UV.
(A) Genes displaying UVA-induced (‘three week’ UVA regimen) up- or downregulation of expression by at least threefold (p < 0.05) as detected using the RT2 Human Stress and Toxicity Pathway Finder™ PCR Expression Array shown in Fig. 4A. (B) Selected genes without significant expression changes in response to UVA exposure (p > 0.05).
| A | ||
|---|---|---|
| gene symbol | fold change | p-value |
| HSPA6 (NM_002155) | 1041.61 | 0.0002 |
| HMOX1 (NM_002133) | 18.05 | 0.0048 |
| HSPA1A (NM_005345) | 11.04 | 0.0026 |
| GDF15 (NM_004864) | 8.93 | 0.0011 |
| CYP2E1 (NM_000773) | 3.87 | 0.0130 |
| HSPH1 (NM_006644) | 3.76 | 0.0012 |
| TXNRD1 (NM_003330) | 3.16 | 0.0218 |
| CDKN1A (NM_000389) | 3.02 | 0.0080 |
| CCL5 (NM_002985) | -5.66 | 0.0128 |
| CCL4 (NM_002984) | -7.65 | 0.0037 |
| CXCL10 (NM_001565) | -11.35 | 0.0199 |