Table 1.

Numbers of mice used in behavioral studies

Figure	Treatment in mice	Serotonergic dose and n values
1A,B	5-HTP (mg/kg, i.p.) ±M100	100	150	200	M100 + 200
	WT, βarr2-KO	n = 13, 8	n = 7, 5	n = 8, 7	n = 6, 6
1C,D	5-HT (μg, i.c.v.) ±M100	10	20	40	M100 + 40
	WT, βarr2-KO	n = 4, 5	n = 7, 5	n = 5, 6	n = 4, 4
1E,F	Veh/Clor (±M100) + 5-HTP	Veh +50	Veh +100	Clor +50	Clor +100	Clor + M100 +100
	WT, βarr2-KO	n = 6, 5	n = 6, 5	n = 5, 6	n = 9, 8	n = 4, 4
2A,B	Veh/MTZ + 5-HTP	Veh + 200	MTZ + 200
	WT, βarr2-KO	n = 4, 5	n = 4, 5
3A,B	N-Me-5-HT (μg, i.c.v.)	10	20	40
	WT, βarr2-KO	n = 4, 4	n = 5, 5	n = 4, 4
3C	Veh/M100 + N-Me-5-HT	Veh + 20	M100 + 20
	WT, βarr2-KO	n = 4, 4	n = 4, 4
3D	Veh/MTZ + N-Me-5-HT	Veh + 20	MTZ + 20
	WT	n = 5	n = 4
3E,F	5-MeO-DMT (mg/kg, i.p.)	5	10	15
	WT, βarr2-KO	n = 9, 10	n = 10, 16	n = 5, 5
3G	Veh/M100 + 5-MeO-DMT	Veh + 10	M100 + 10
	WT, βarr2-KO	n = 5, 9	n = 5, 5
3H	Veh/MTZ + 5-MeO-DMT	Veh + 10	MTZ + 10
	C57BL/6	n = 6	n = 4
6A,B	Veh, LY, PP2, AKTi + 5-HTP	Veh + 200	LY + 200	PP2 + 200	AKTi + 200
	C57BL/6	n = 10	n = 5	n = 5	n = 5
6C	Veh, AKTi + 5-MeO-DMT	10	AKTi + 200
	C57BL/6	n = 6	n = 4
7A,B	Veh, LY, PP2, AKTi + 5-HTP	200	LY + 200	PP2 + 200	AKTi + 200
	βbarr2-KO	n = 7	n = 6	n = 6	n = 6
8A,B	Veh, AKTi, MTZ, AKTi + MTZ + 5-HTP	200	MTZ + 200	AKTi + 200	MTZ + AKTi +200
	WT	n = 11	n = 6	n = 5	n = 5

Veh, Vehicle; 5-HT, serotonin; M100, M100907; Clor, clorgyline; N-Me-5-HT, N-methylserotonin; LY, LY294002. Serotonergic dosing routes: 5-HTP, mg/kg, i.p.; 5-HT and N-methylserotonin, μg, i.c.v.; 5-MeO-DMT, mg/kg, i.p. For inhibitor and antagonist dosage information, see Materials and Methods.