Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Feedback loop responsible for initiating and maintaining growth arrest in senescent cells (adapted from Passos et al. [23]). Damage may arise in mitochondria, by telomere erosion, or by induction of lesions in non-telomeric chromosomal DNA. Once initiated, feedback proceeds (see text), eventually locking the cell in a state of permanent arrest.
