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. Author manuscript; available in PMC: 2011 Oct 29.
Published in final edited form as: Immunity. 2010 Oct 29;33(4):516–529. doi: 10.1016/j.immuni.2010.10.006

Figure 2. Construction of a Generic Vaccine Chip.

Figure 2

Top: Systems biology approaches allow the identification of predictive gene signatures of immunogenicity for many vaccines. Vaccines with similar correlates of protection may or may not share the same gene markers. The identification of predictive signatures of many vaccines would enable the development of a vaccine chip. Bottom: This chip would consist of perhaps a few hundred genes, subsets of which would predict a particular type of innate or adaptive immune response (e.g. magnitude of effector CD8+ T cell response, frequency of polyfunctional T cells, balance of T helper 1 (Th1), Th2 and Th17 cells, high-affinity antibody titers and so on). This would allow the rapid evaluation of vaccinees for the strength, type, duration and quality of protective immune responses stimulated by the vaccine. Thus, the vaccine chip is a device that could be used to predict immunogenicity and protective capacity of virtually any vaccine in the future.