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Schematic representations of possible pathways of diffusion. Top, Side view of paranodal loops. Middle, Tangential view. Pathway 1 goes through the junctional cleft across the transverse bands. Pathway 2 also goes through the junctional cleft but passes along the transverse bands at ∼8 degrees from transverse. Pathway 3 does not go through the junctional cleft but passes between paranodal loops. Bottom, Longitudinal view of pathway 3 winding helically around an axon.
