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. Author manuscript; available in PMC: 2011 Dec 7.
Published in final edited form as: Biochemistry. 2010 Nov 12;49(48):10287–10297. doi: 10.1021/bi100500m

Figure 4. Ca2+ -dependent changes in amide chemical shifts of C-CaM in the presence of PEP-19 show decreased cooperativity.

Figure 4

Various ratios of [Ca2+]/[C-CaM] between 0 and 2.0 are indicated. Exchange characteristics for Thr117 shown in Panel (A) indicate lower degree of cooperativity of Ca2+ binding in the presence of PEP-19. Exchange characteristics for Gly98 in Ca2+ binding site III and Gly134 in the Ca2+ binding site IV shown in Panel (B) indicates preferential binding of the 1st Ca2+ to site IV.