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. Author manuscript; available in PMC: 2011 May 19.
Published in final edited form as: Science. 2010 Oct 28;330(6007):1108–1112. doi: 10.1126/science.1195298

Fig. 2.

Fig. 2

Reconsolidation update performed soon after fear conditioning (FC) erases fear. (A) Experimental groups. Ret, retrieval; Ext, extinction. (B and C) CS-evoked freezing during conditioning and extinction. (D to F) Freezing was averaged for the first and last four trials of extinction. Spontaneous recovery (Spont Rec) and renewal were assessed by test comparison with the last four trials of extinction. Repeated-measures ANOVA revealed a significant group × test interaction in (D) [F3,39 = 10.1, P < 0.0001 (n = 7 to 8 mice)] and (E) [F3,36 = 9.6, P < 0.0001 (n = 7 to 8 mice)] but not in (F) [F3,36 = 0.34, P = 0.80 (n = 6 to 8 mice)]. *P < 0.001, Tukey’s post-hoc comparison with the last four trials. #P < 0.0001. (G) Effect of systemic AIDA 1 hour before retrieval extinction (Ret-Ext). Repeated-measures ANOVA, treatment × test: F3,48 = 4.95, P < 0.01 (n = 8 to 10 mice). *P < 0.01, Tukey’s post-hoc comparison with the last four trials. #P < 0.01.