Table 2.
Determinants of 25(OH)D (ng/ml) decrease on HAART
| Variable | 25(OH)D (CI) pre-HAART | 25(OH)D (CI) post-HAART | Adj p |
|---|---|---|---|
| Population | 24.6 (22.1;27.0) | 22.0 (19.8;24.1) | 0.001* |
| Sex | 0.668 | ||
| M | 25.6 (22.8;28.4) | 22.8 (20.4;25.3) | |
| F | 19.6 (14.8;24.4) | 17.8 (14.0;21.6) | |
| Skin color | 0.195 | ||
| Light | 26.7 (24.0;29.4) | 23.6 (21.2;26.0) | |
| Dark | 15.8 (11.9;19.7) | 15.3 (11.6;19.0) | |
| Pre-HAART sampling | 0.127 | ||
| Winter | 21.9 (18.1;25.6) | 19.8 (16.2;23.5) | |
| Spring | 22.1 (16.5;27.6) | 22.4 (19.3;25.5) | |
| Summer | 29.8 (24.2;35.4) | 22.4 (19.7;29.0) | |
| Fall | 24.8 (19.1;30.5) | 22.5 (16.8;28.2) | |
| Age | 0.644 | ||
| <35 years | 24.9 (21.0;28.7) | 22.2 (18.6;25.8) | |
| 35-50 years | 24.2 (20.2;28.2) | 21.2 (17.8;24.5) | |
| >50 years | 24.8 (20.0;29.6) | 24.2 (19.2;29.2) | |
| Weight (Kg) | 0.008 | ||
| ≤70 | 23.0 (19.4;26.6) | 18.5 (16.2;20.9) | |
| >70 | 25.8 (22.4;29.2) | 24.8 (21.4;28.1) | |
| CD4 (CD4/mm3) nadir | 0.160 | ||
| ≤200 | 25.4 (21.0;29.8) | 21.3 (18.2;24.5) | |
| >200 | 24.1 (21.1;27.1) | 22.3 (19.4;25.3) | |
| CD4 (CD4/mm3) pre-HAART | 0.174 | ||
| ≤200 | 25.9 (20.5;31.4) | 21.5 (17.4;25.6) | |
| >200 | 24.1 (21.3;26.9) | 22.1 (19.5;24.8) | |
| Viral Load (log10) | 0.666 | ||
| >5 | 25.7 (22.9;28.6) | 22.9 (20.3;25.6) | |
| ≤5 | 21.7 (16.7;26.6) | 19.6 (15.8;23.5) | |
| HIV stage (CDC) | 0.760 | ||
| A | 25.4 (22.4;28.4) | 22.7 (20.0;25.3) | |
| B | 24.3 (18.0;30.5) | 21.0 (15.7;26.4) | |
| C | 19.8 (13.0;26.5) | 18.7 (11.8;25.6) | |
| Therapy | 0.001 | ||
| NNRTI | 26.6 (22.5;30.8) | 21.6 (17.8;25.5) | |
| PI | 22.6 (19.9;25.3) | 22.3 (20.1;24.6) |
p: p-value for comparison between groups (linear regression); adj p: p-value from final multivariate model (after backwards elimination); CI: 95% confidence interval; * non adjusted p value