Table 2. Biochemical follow-up.

	Supplementation of vitamin D3								Follow-up after cessation
	W0		W6			W12			W16			W24
Parameter	Median	(Min–Max)	Median	(Min–Max)	PB	Median	(Min–Max)	PB	Median	(Min–Max)	PB	Median	(Min–Max)	PB
25-hydroxyvitamin D	50	31–175	285**	122–401	0.001	380**	151–535	0.001	-	-	-	-	-	-
1,25-dihydroxyvitamin D	146	58–272	208**	99–434	0.002	202**	90–400	0.003	-	-	-	-	-	-
Total calcium (mmol/L)	2.3	(2.2–2.5)	2.4	(2.2–2.5)	0.133	2.4	(2.2–2.5)	0.208	2.4	(2.2–2.5)	0.176	2.4	(2.2–2.5)	0.337
Albumin (g/L)	39	(32–47)	39	(31–44)	0.134	39	(31–46)	0.606	39	(31–43)	0.284	38	(31–46)	0.546
Corrected calcium (mmol/L)A	2.36	(2.14–2.52)	2.38*	(2.32–2.56)	0.048	2.42	(2.26–2.50)	0.082	2.40	(2.24–2.58)	0.069	2.38	(2.24–2.50)	0.396
Phosphorus (mmol/L)	1.0	(0.7–1.1)	1.1	(0.8–1.4)	0.057	1.1**	(0.9–1.5)	0.008	1.0*	(0.8–1.4)	0.023	1.0	(0.8–1.3)	0.383
PTH (pmol/L)	4.6	(1.9–10.5)	2.8**	(1.7–6.7)	0.003	-	-	-	3.5**	(0.9–9.6)	0.003	3.3*	(0.4–7.5)	0.003
Sodium (mmol/L)	139	(136–142)	139	(138–143)	0.150	141**	(138–143)	0.005	140*	(137–142)	0.048	140	(136–142)	0.080
Potassium (mmol/L)	4.1	(3.4–4.6)	4.0	(3.5–4.6)	0.414	4.5**	(3.6–4.7)	0.008	4.3	(3.6–4.7)	0.555	4.0	(3.7–4.3)	0.133
Urea (mmol/L)	3.5	(2.3–6.0)	3.5	(2.4–6.9)	0.776	3.7	(2.6–6.4)	0.221	3.8	(2.7–5.8)	0.073	3.9	(2.6–6.0)	0.055
Creatinine (µmol/L)	65	(47–84)	69	(49–99)	0.060	73*	(49–109)	0.018	74*	(49–97)	0.012	73	(41–93)	0.064
AST (U/L)	31	(21–42)	32	(21–40)	0.820	-	-	-	29	(20–52)	0.955	28	(19–51)	0.955
ALT (U/L)	34	(19–95)	33	(22–80)	0.975	-	-	-	32	(19–120)	0.670	30	(17–48)	0.900
ALP (U/L)	67	(42–93)	62	(45–85)	0.529	-	-	-	69	(43–85)	0.950	68	(49–99)	0.442

^ACalculated with the formula: Calcium_corr (mmol/L)  =  total Calcium (mmol/L)+ [(40 – Albumin (g/L))*0.02].

^BDifference when compared to baseline levels was tested with the Wilcoxon Signed-Ranks test.

*P<0.050;

**P<0.010.