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. Author manuscript; available in PMC: 2010 Dec 14.
Published in final edited form as: J Coagul Disord. 2010 Jul 1;2(2):19–27.

Figure 4. Graphic representation of missense mutations per FVIII.

Figure 4

The number of hemophilia A causing mutations in FVIII was determined in 40 residue blocks, including the signal peptide. Mutations were derived from the Haemophilia A Mutation Database (http://hadb.org.uk), and mutations resulting in introduction of a stop codon were excluded. A schematic domain representation of FVIII is shown, indicating the location of the 40 residue stretches.